IsoTag™ Reagents for Non-Chromatographic Purification of Viral Vectors
Kelli Luginbuhl, General Manager, Isolere Bio by Donaldson, from BioProcess International 2023. View the full interview →
IsoTag™ Products
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IsoTag™ AAV Reagent
Evaluation kit & reagent, available now!
IsoTag™ AAV enables downstream concentration and purification for a broad spectrum of adeno-associated virus (AAV) serotypes.
Achieve breakthrough yield and purity in under 4 hours with minimal optimization, for a variety of AAV serotypes with neutral pH elution buffer options.
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IsoTag™ LV Reagent
IsoTag™ LV enables concentration and purification of VSV-G pseudotyped vectors of varied serotype or virus-like particles.
This reagent and process improves lentivirus stability, enables rapid concentration, and maintains functional titers with mild elution conditions.
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IsoTag™ ssRNA Reagent
Prototype reagent, coming soon!
The presence of dsRNA poses several unique challenges for mRNA vaccines. This reagent has been designed to specifically bind to ssRNA, as a method to remove dsRNA and other unwanted impurities.
We are seeking partners and alpha testers to accelerate its path to commercialization. Please contact us if you are interested.
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Pipeline Development
New applications for the IsoTag™ platform are being explored with adenovirus, pDNA, mAbs, enzymes, and other complex biologics that require tailored purification solutions.
We have developed multi-scaffold libraries that allow us to rapidly select affinity ligands for any target biologic of interest. Once selected, the ligand can be quickly dropped into our platform, or further tailored to meet the specific needs of your target.
high purity
& high yield
IsoTag™ reagents are paired with a platform process that uses existing equipment and off-the-shelf consumables to achieve high purity and high yield in a single shift.
We are proud to collaborate with:
